Serum concentrations of persistent organic pollutants mixture during pregnancy and anogenital distance in 8-year-old children from the INMA-Asturias cohort.
Por:
García-Villarino M, Signes-Pastor AJ, Riaño-Galán I, Rodríguez-Dehli AC, Vizcaíno E, Grimalt JO, Fernández-Somoano A and Tardón A
Publicada:
1 oct 2022
Ahead of Print:
9 jun 2022
Resumen:
BACKGROUND: During pregnancy, women are commonly exposed to several endocrine-disrupting chemicals, including persistent organic pollutants (POPs). These compounds can transfer to the fetus through the placenta. Prenatal POP exposure is related to altered fetal genital and reproductive tract development. However, the relationship between exposure to POP mixtures and anogenital distance (AGD) is poorly investigated. This study investigated the association between prenatal exposure to POP mixtures and AGD in 8-year-old children. METHODS: Data were collected from the INMA-Asturias cohort. Maternal serum POP concentrations were measured during the first trimester of pregnancy. Anoscrotal distance (AGD(AS)) and anopenile distance (AGD(AP)) in males and anofourchetal distance (AGD(AF)) and anoclitoral distance (AGD(AC)) in females were recorded in 362 8-years-olds. Conventional linear regression, and the novel weighted quantile sum regression (WQSR) and Bayesian kernel machine regression (BKMR) models were applied to assess the relationships between AGD and POPs exposure stratified by sex. RESULTS: Among males, in the linear regression, b-hexachlorocyclohexane, PCB138, PCB153, and PCB180 were inversely associated with the anogenital index (AGI)(AS) (-0.06 mm/kg (95% confidence interval [CI]: -0.11, -0.02), -0.07 mm/kg (95% CI: -0.14, -0.01), -0.07 mm/kg (95% CI: -0.13, -0.01), and -0.08 mm/kg (95% CI: -0.14, -0.02), respectively). Among females, polybrominated diphenyl ether (PBDE)47 and PBDE154 were positively associated with increased AGI(AF) (0.02 mm/kg (95% CI: 0.00, 0.03) and 0.09 mm/kg (95% CI: 0.01, 0.17), respectively). BKMR confirmed these associations. WQSR found a negative combined effect of the POP mixture on AGD, and PCB138, PCB153, and PCB180 (weighted 0.18, 0.13, and 0.09, respectively) were identified as the most impacting chemicals. In females, WQSR found a positive combined effect and determined PBDE47 (weighted 0.35) as the most impacting. CONCLUSIONS: Maternal exposure to a POP mixture was negatively associated with AGD in male children and positively associated with AGD in female children, thus providing evidence of the adverse effects of POPs on genital development.
Filiaciones:
García-Villarino M:
Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain
Unidad de Epidemiología Molecular del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA) - Departamento de Medicina, Universidad de Oviedo, Julián Clavería Street s/n, 33006, Oviedo, Asturias, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, Spain
:
Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain
Unidad de Epidemiología de la Nutrición, Universidad Miguel Hernández, Alicante, Spain
Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Spain
Riaño-Galán I:
Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, Spain
Servicio de Pediatría, Endocrinología Pediátrica, HUCA, Roma Avenue s/n, 33001, Oviedo, Asturias, Spain
Rodríguez-Dehli AC:
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, Spain
Servicio de Pediatría, Hospital San Agustín, Heros Street, 4, 33410, Avilés, Asturias, Spain
Vizcaíno E:
Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona Street, 18-26, 08034, Barcelona, Cataluña, Spain
Grimalt JO:
Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona Street, 18-26, 08034, Barcelona, Cataluña, Spain
Fernández-Somoano A:
Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain
Unidad de Epidemiología Molecular del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA) - Departamento de Medicina, Universidad de Oviedo, Julián Clavería Street s/n, 33006, Oviedo, Asturias, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, Spain
Tardón A:
Spanish Consortium for Reseaiologrch on Epidemy and Public Health (CIBERESP), Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain
Unidad de Epidemiología Molecular del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA) - Departamento de Medicina, Universidad de Oviedo, Julián Clavería Street s/n, 33006, Oviedo, Asturias, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, Spain
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