Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake.
Por:
Collatuzzo G, Alicandro G, Bertuccio P, Pelucchi C, Bonzi R, Palli D, Ferraroni M, Ye W, Plymoth A, Zaridze D, Maximovich D, Aragones N, Castaño-Vinyals G, Vioque J, Garcia de la Hera M, Zhang ZF, Hu J, Lopez-Carrillo L, López-Cervantes M, Dalmartello M, Mu L, Ward MH, Rabkin C, Yu GP, Camargo MC, Curado MP, Lunet N, Negri E, La Vecchia C and Boffetta P
Publicada:
1 oct 2022
Ahead of Print:
13 jul 2022
Resumen:
BACKGROUND: Peptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC. METHODS: We conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC. RESULTS: PUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC. CONCLUSIONS: Our study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.
Filiaciones:
Collatuzzo G:
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
Alicandro G:
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
Cystic Fibrosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Bertuccio P:
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, Milan, Italy
Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy
Pelucchi C:
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, Milan, Italy
Bonzi R:
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, Milan, Italy
Palli D:
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy
Ferraroni M:
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, Milan, Italy
Ye W:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Plymoth A:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Zaridze D:
Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia
Maximovich D:
Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia
Aragones N:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Cancer Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
Castaño-Vinyals G:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Barcelona Institute for Global Health-ISGlobal, Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), Alicante, Spain
:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), Alicante, Spain
Zhang ZF:
Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
Hu J:
Harbin Medical University, Harbin, People's Republic of China
Lopez-Carrillo L:
Mexico National Institute of Public Health, Morelos, Mexico
López-Cervantes M:
Facultad de Medicina, UNAM. Coyoacán, Mexico
Dalmartello M:
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, Milan, Italy
Mu L:
Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
Ward MH:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Rabkin C:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Yu GP:
Medical Informatics Center, Peking University, Peking, People's Republic of China
Camargo MC:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Curado MP:
Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil
Lunet N:
EPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal
Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, Portugal
Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Negri E:
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, Milan, Italy
La Vecchia C:
Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, Milan, Italy
Boffetta P:
Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA
Green Accepted
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