The cognitive and psychiatric subacute impairment in severe Covid-19
Por:
Serrano-Castro, P, Garzon-Maldonado, F, Casado-Naranjo, I, Ollero-Ortiz, A, Minguez-Castellanos, A, Iglesias-Espinosa, M, Baena-Palomino, P, Sanchez-Sanchez, V, Sanchez-Perez, R, Rubi-Callejon, J, Estevez-Maria, J, Galeano-Bilbao, B, Romero-Imbroda, J, Sobrino, B, Arrabal-Gomez, C, Oliver-Martos, B, Munoz-Becerra, L, Requena, N, de Sotomayor, M, Estivill-Torrus, G, Suarez, J, Ciano-Petersen, N, Pons-Pons, G, Reyes-Bueno, J, Cabezudo-Garcia, P, Aguilar-Castillo, M, Cosme, C, Duque-Holguera, M, Cuartero-Rodriguez, E, Vilches-Carrillo, R, Carrera-Munoz, I, Carnero-Pardo, C, Ramirez-Garcia, T, Oropesa, J, Dominguez-Mayoral, A, Pelaez-Vinas, N, Valiente, L and de Fonseca, F
Publicada:
3 mar 2022
Ahead of Print:
3 mar 2022
Resumen:
Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases.
Filiaciones:
Serrano-Castro, P:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Hosp Reg Univ Malaga Espana, Inst IBIMA, Neurol Dept, Avda Carlos Haya S-N,4a Planta, Malaga, Spain
Garzon-Maldonado, F:
Virgen Victoria Univ Hosp, Neurol Serv, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Casado-Naranjo, I:
Univ Hosp Caceres, Neurol Serv, Caceres, Spain
Biomed Network Res Ctr Neurodegenerat Dis CIBERNE, Madrid, Spain
Univ Inst Biosanitary Res Extremadura INUBE, Caceres, Spain
Ollero-Ortiz, A:
Valme Univ Hosp, Neurol Serv, Seville, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Minguez-Castellanos, A:
Virgen Nieves Univ Hosp, Neurol Serv, Granada, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Inst Biosanitary Res Granada Ibs GRANADA, Granada, Spain
Iglesias-Espinosa, M:
Torrecardenas Univ Hosp, Neurol Serv, Almeria, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Baena-Palomino, P:
Torrecardenas Univ Hosp, Neurol Serv, Almeria, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Sanchez-Sanchez, V:
Virgen Macarena Univ Hosp, Neurol Serv, Seville, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
:
Univ Hosp Alicante, Neurol Serv, Alicante, Spain
Rubi-Callejon, J:
Hosp Poniente Almeria, Internal Med Serv, Neurol Unit, El Ejido, Almeria, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Estevez-Maria, J:
Reina Sofia Univ Hosp, Neurol Serv, Cordoba, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Galeano-Bilbao, B:
Puerta Mar Univ Hosp, Neurol Serv, Cadiz, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Romero-Imbroda, J:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Hosp Quiron Salud Malaga, Neurol Serv, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Sobrino, B:
Reg Univ Hosp Malaga, Infect Dis Serv, Malaga, Spain
Arrabal-Gomez, C:
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Oliver-Martos, B:
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Munoz-Becerra, L:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Requena, N:
Virgen Victoria Univ Hosp, Neurol Serv, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
de Sotomayor, M:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Estivill-Torrus, G:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Suarez, J:
Inst Biomed Res Malaga IBIMA, Neuropsychopharmacol Grp, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Ciano-Petersen, N:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Pons-Pons, G:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Reyes-Bueno, J:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Cabezudo-Garcia, P:
Reg Univ Hosp Malaga, Neurol Serv, Malaga, Spain
Inst Biomed Res Malaga IBIMA, Neuroimmunol & Neuroinflamat Grp, Malaga, Spain
Aguilar-Castillo, M:
Reg Univ Hosp Malaga, Biotechnol Unit, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Cosme, C:
Virgen Victoria Univ Hosp, Neurol Serv, Malaga, Spain
Duque-Holguera, M:
Univ Hosp Caceres, Neurol Serv, Caceres, Spain
Cuartero-Rodriguez, E:
Valme Univ Hosp, Neurol Serv, Seville, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Vilches-Carrillo, R:
Virgen Nieves Univ Hosp, Neurol Serv, Granada, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Carrera-Munoz, I:
Virgen Nieves Univ Hosp, Neurol Serv, Granada, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Carnero-Pardo, C:
Fydian Neuroctr, Granada, Spain
Ramirez-Garcia, T:
Torrecardenas Univ Hosp, Neurol Serv, Almeria, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Oropesa, J:
Juan Ramon Jimenez Univ Hosp, Neurol Serv, Huelva, Spain
Dominguez-Mayoral, A:
Virgen Macarena Univ Hosp, Neurol Serv, Seville, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Pelaez-Vinas, N:
Reina Sofia Univ Hosp, Neurol Serv, Cordoba, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Valiente, L:
Reg Univ Hosp Malaga, Infect Dis Serv, Malaga, Spain
de Fonseca, F:
Inst Biomed Res Malaga IBIMA, Neuropsychopharmacol Grp, Malaga, Spain
Andalusian Network Clin & Translat Res Neurol NEU, Malaga, Spain
Hosp Reg Univ Malaga Espana, Inst IBIMA, Neuropsychopharmacol Grp, Avda Carlos Haya S-N, Malaga, Spain
gold, Green Published, Green Submitted
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