Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain
Por:
Petermann-Rocha, F, Valera-Gran, D, Fernandez-Pires, P, Martens, D, Julvez, J, Rodriguez-Dehli, C, Andiarena, A, Lozano, M, Fernandez-Somoano, A, Lertxundi, A, Llop, S, Guxens, M, Nawrot, T and Navarrete-Munoz, E
Publicada:
1 abr 2023
Ahead of Print:
1 ago 2022
Resumen:
Background Inadequate sleep duration has been suggested as a chronic stressor associated with changes in telomere length (TL). This study aimed to explore the association between sleep duration and TL using the INMA birth cohort study data. Methods A total of 1014 children were included in this study (cross-sectional: 686; longitudinal: 872). Sleep duration (h/day) was reported by caregivers at 4 years and classified into tertiles (7-10 h/day; >10-11 h/day; >11-14 h/day). Leucocyte TL at 4 and 7-9 years were measured using quantitative PCR methods. Multiple robust linear regression models, through log-level regression models, were used to report the % of difference among tertiles of sleep duration. Results In comparison to children who slept between >10 and 11 h/day, those in the highest category (more than 11 h/day) had 8.5% (95% CI: 3.56-13.6) longer telomeres at 4 years. Longitudinal analysis showed no significant association between sleep duration at 4 years and TL at 7-9 years. Conclusion Children who slept more hours per day had longer TL at 4 years independently of a wide range of confounder factors. Environmental conditions, such as sleep duration, might have a major impact on TL during the first years of life. Impact Telomere length was longer in children with longer sleep duration (>11 h/day) independently of a wide range of confounder factors at age 4 and remained consistent by sex. Sleep routines are encouraged to promote positive child development, like the number of hours of sleep duration. Considering the complex biology of telomere length, future studies still need to elucidate which biological pathways might explain the association between sleep duration and telomere length.
Filiaciones:
Petermann-Rocha, F:
Univ Diego Portales, Fac Med, Santiago, Chile
Univ Glasgow, Inst Cardiovasc Med Sci, Glasgow, Lanark, Scotland
Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
:
Miguel Hernandez Univ, Dept Surg & Pathol, Alicante 03550, Spain
Miguel Hernandez Univ, Grp Invest Terapia Ocupac InTeO, Alicante 03550, Spain
:
Miguel Hernandez Univ, Dept Surg & Pathol, Alicante 03550, Spain
Martens, D:
Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium
Julvez, J:
Hosp Univ Sant Joan Reus, Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain
Rodriguez-Dehli, C:
Hosp San Agustin, Serv Pediatr, Heros St 4, Asturias, Spain
Inst Invest Sanitaria Principado Asturias ISP, Roma Ave S-N, Roma, Spain
Andiarena, A:
Hlth Res Inst BIODONOSTIA, Donostia San Sebastian, Spain
Univ Basque Country UPV EHU, Fac Psychol, San Sebastian, Spain
Lozano, M:
Univ Valencia, Toxicol & Forens Med Dept, Prevent Med & Publ Hlth, Food Sci, Valencia, Spain
Univ Valencia, Univ Jaume 1, Epidemiol & Environm Hlth Joint Res Unit, ISABIO, Valencia, Spain
Fernandez-Somoano, A:
Spanish Consortium Res Epidemiol & Publ Hlth CIB, Madrid, Spain
Univ Oviedo, Inst Univ Oncol Principado Asturias IUOPA, Unidad Epidemiol Mol Canc, Dept Med, Julian Claveria St,S-N, Asturias 33006, Spain
Lertxundi, A:
Spanish Consortium Res Epidemiol & Publ Hlth CIB, Madrid, Spain
Univ Basque Country UPV EHU, Prevent Med & Publ Hlth Dept, Leioa, Spain
Llop, S:
Univ Valencia, Univ Jaume 1, Epidemiol & Environm Hlth Joint Res Unit, ISABIO, Valencia, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIB, Madrid, Spain
Guxens, M:
Spanish Consortium Res Epidemiol & Publ Hlth CIB, Madrid, Spain
ISGlobal, Barcelona, Spain
Univ Pompeu Fabra, Barcelona, Spain
Univ Med Ctr, Dept Child & Adolescent Psychiat Psychol, Erasmus MC, Rotterdam, Netherlands
Nawrot, T:
Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium
:
Miguel Hernandez Univ, Dept Surg & Pathol, Alicante 03550, Spain
Miguel Hernandez Univ, Grp Invest Terapia Ocupac InTeO, Alicante 03550, Spain
Miguel Hernandez Univ, Alicante Inst Hlth & Biomed Res ISABIAL, Dept Surg & Pathol, Alicante 03550, Spain
Green Accepted
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