Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.
Por:
Signes-Pastor AJ, Romano ME, Jackson B, Braun JM, Yolton K, Chen A, Lanphear B and Karagas MR
Publicada:
7 ago 2022
Ahead of Print:
7 ago 2022
Resumen:
Arsenic exposure during pregnancy may increase the risk for intellectual deficits in children, but limited data exist from prospective epidemiologic studies, particularly at low arsenic exposure levels. We investigated the association between prenatal maternal urinary arsenic concentrations and childhood cognitive abilities in the Health Outcomes and Measures of the Environment (HOME) Study. We used anion exchange chromatography coupled with inductively coupled plasma mass spectrometry detection to measure arsenic species content in pregnant women's urine. The summation of inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) refers to ?As. We assessed children's cognitive function (n = 260) longitudinally at 1-, 2-, and 3-years using Bayley Scales of Infant and Toddler Development, at 5 years using Wechsler Preschool and Primary Scale of Intelligence, and at 8 years using Wechsler Intelligence Scale for Children. We observed a modest decrease in mental development index and full-scale intelligence quotient at ages 3 and 5 years with each doubling of ?As with estimated score (ß) differences and 95% confidence interval (CI) of -1.8 from -4.1 to 0.5 and -2.5 from -5.1 to 0.0, respectively. This trend was stronger and reached statistical significance among children whose mothers had lower iAs methylation capacity and low urinary arsenobetaine concentrations. Our findings suggest that arsenic exposure levels relevant to the general US population may affect children's cognitive abilities.
Filiaciones:
:
Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA
Unidad de Epidemiología de la Nutrición. Universidad Miguel Hernández, Alicante, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Spain
Romano ME:
Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA
Jackson B:
Department of Earth Sciences, Dartmouth College, Hanover, NH, USA
Braun JM:
Department of Epidemiology, Brown University, Providence, RI, USA
Yolton K:
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Chen A:
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Lanphear B:
Child and Family Research Institute, BC Children's and Women's Hospital, Vancouver, BC, Canada
Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada
Karagas MR:
Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA
Green Accepted, hybrid
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