Environment and cardiovascular health: causes, consequences and opportunities in prevention and treatment.
Por:
Bañeras J, Iglesies-Grau J, Téllez-Plaza M, Arrarte V, Báez-Ferrer N, Benito B, Campuzano Ruiz R, Cecconi A, Domínguez-Rodríguez A, Rodríguez-Sinovas A, Ujueta F, Vozzi C, Lamas GA and Navas-Acién A
Publicada:
1 dic 2022
Ahead of Print:
2 ago 2022
Resumen:
The environment is a strong determinant of cardiovascular health. Environmental cardiology studies the contribution of environmental exposures with the aim of minimizing the harmful influences of pollution and promoting cardiovascular health through specific preventive or therapeutic strategies. The present review focuses on particulate matter and metals, which are the pollutants with the strongest level of scientific evidence, and includes possible interventions. Legislation, mitigation and control of pollutants in air, water and food, as well as environmental policies for heart-healthy spaces, are key measures for cardiovascular health. Individual strategies include the chelation of divalent metals such as lead and cadmium, metals that can only be removed from the body via chelation. The TACT (Trial to Assess Chelation Therapy, NCT00044213) clinical trial demonstrated cardiovascular benefit in patients with a previous myocardial infarction, especially in those with diabetes. Currently, the TACT2 trial (NCT02733185) is replicating the TACT results in people with diabetes. Data from the United States and Argentina have also shown the potential usefulness of chelation in severe peripheral arterial disease. More research and action in environmental cardiology could substantially help to improve the prevention and treatment of cardiovascular disease.
Filiaciones:
Bañeras J:
Servei de Cardiologia, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain
Iglesies-Grau J:
Centre ÉPIC and Research Center, Montreal Heart Institute, Montreal, Quebec, Canadá
Téllez-Plaza M:
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain
:
Servicio de Cardiología, Hospital General Universitario Dr. Balmis, ISABIAL, Alicante, Spain
Báez-Ferrer N:
Servicio de Cardiología, Hospital Universitario de Canarias, Universidad Europea de Canarias, Santa Cruz de Tenerife, Spain
Benito B:
Servei de Cardiologia, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain
Campuzano Ruiz R:
Servicio de Cardiología, Hospital Universitario Fundación de Alcorcón, Alcorcón, Madrid, Spain
Cecconi A:
Servicio de Cardiología, Hospital Universitario de La Princesa, Madrid, Spain
Domínguez-Rodríguez A:
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain
Servicio de Cardiología, Hospital Universitario de Canarias, Universidad Europea de Canarias, Santa Cruz de Tenerife, Spain
Rodríguez-Sinovas A:
Servei de Cardiologia, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain
Ujueta F:
Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, Florida, United States
Vozzi C:
Departamento de Cardiología, Instituto Vozzi, Rosario, Argentina
Lamas GA:
Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, Florida, United States
Department of Medicine, Mount Sinai Medical Center, Miami Beach, Florida, United States
Navas-Acién A:
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, Nueva York, United States
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