The association between maternal ultra-processed food consumption during pregnancy and child neuropsychological development: A population-based birth cohort study
Por:
Puig-Vallverdu, J, Romaguera, D, Fernandez-Barres, S, Gignac, F, Ibarluzea, J, Santa-Maria, L, Llop, S, Gonzalez, S, Vioque, J, Riano-Galan, I, Fernandez-Tardon, G, Pinar, A, Turner, M, Arija, V, Salas-Savado, J, Vrijheid, M and Julvez, J
Publicada:
1 oct 2022
Ahead of Print:
19 ago 2022
Resumen:
Background & aims: Maternal ultra-processed food (UPF) consumption during pregnancy may adversely affect child development. Pregnancy sugar-sweetened beverage consumption (as a part of UPF) has been associated with child cognitive dysfunction in the general population, but the role of total UPF con-sumption during pregnancy in later child neuropsychological development has not been studied. We aimed to analyse the association between maternal pregnancy UPF consumption and child neurodevelopment.Methods: This study involved 2377 pairs of pregnant women and their offspring from a Spanish birth cohort (recruitment period: 2004e20 08, INMA project). Dietary intake was estimated using a 101-item food frequency questionnaire in the third trimester of pregnancy. The NOVA classification was used to identify UPFs, and their consumption was calculated as the daily percentage of total food consumption and categorized into tertiles. Child neuropsychological development was assessed with the Bayley Scales of Infant and Toddler Development (1-year-old, n = 1929) and the McCarthy Scales of Children's Abilities (4-5 years-old, n = 1679). Potential associations were analysed using multivariate linear regression models adjusted for a range of family and child characteristics.Results: UPF consumption among pregnant women represented an average of 17% of the total diet, with sugar-sweetened beverages being the most commonly consumed type of UPF (40%). Children born to mothers in the highest tertile of UPF consumption (28.9% or more of the total diet) vs the lowest tertile (7.2% or less), showed a lower score (B =-2.29 [95% Confidence Interval (CI),-4.13;-0.46]) in the Verbal Scale of the McCarthy Scales (p-for-trend = 0.02). No associations were observed with the McCarthy Scales assessing other cognitive domains or with the Bayley Scales.Conclusion: Of the seven cognitive domains studied, we observed an adverse association between maternal consumption of UPF during pregnancy and verbal functioning in early childhood, which is an important cognitive domain of neurodevelopment.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
Puig-Vallverdu, J:
Univ Pompeu Fabra, Barcelona, Catalonia, Spain
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
Romaguera, D:
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain
Hosp Univ Son Espases, Inst Invest Sanitaria Illes Balears IdISBa, Palma De Mallorca, Spain
Fernandez-Barres, S:
Univ Pompeu Fabra, Barcelona, Catalonia, Spain
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Gignac, F:
Univ Pompeu Fabra, Barcelona, Catalonia, Spain
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
Ibarluzea, J:
Biodonostia Hlth Res Inst, Paseo Doctor Begiristain S-N, San Sebastian 20013, Spain
Subdirectorate Publ Hlth Gipuzkoa, Dept Hlth Basque Govt, Ave Navarra 4, San Sebastian 20013, Spain
Inst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, C Monforte Lemos 3-5, Madrid 28029, Spain
Univ Basque Country UPV EHU, Ave Tolosa 70, San Sebastian 20018, Spain
Santa-Maria, L:
Biodonostia Hlth Res Inst, Paseo Doctor Begiristain S-N, San Sebastian 20013, Spain
Subdirectorate Publ Hlth Gipuzkoa, Dept Hlth Basque Govt, Ave Navarra 4, San Sebastian 20013, Spain
Inst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, C Monforte Lemos 3-5, Madrid 28029, Spain
Llop, S:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Valencia, Univ Jaume 1, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain
:
Miguel Hernandez Univ, Dept Publ Hlth Hist Med & Gynecol, Elche, Spain
FISABIO Fdn, Inst Hlth & Biomed Res ISABIAL, Valencia, Spain
:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
FISABIO Fdn, Inst Hlth & Biomed Res ISABIAL, Valencia, Spain
Riano-Galan, I:
CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Hosp Univ Cent Asturias HUCA, Serv Pediat Endocrinol, Oviedo 33011, Spain
Fernandez-Tardon, G:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Pinar, A:
Univ Pompeu Fabra, Barcelona, Catalonia, Spain
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Clin & Epidemiol Neurosci NeuroEpia, Reus, Catalonia, Spain
Turner, M:
Univ Pompeu Fabra, Barcelona, Catalonia, Spain
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Arija, V:
Univ Rovira & Virgili URV, Nutr & Mental Hlth Res Grp NUTRISAM, Tarragona, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Tarragona, Spain
Salas-Savado, J:
CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Tarragona, Spain
Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain
Vrijheid, M:
Univ Pompeu Fabra, Barcelona, Catalonia, Spain
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Julvez, J:
Univ Pompeu Fabra, Barcelona, Catalonia, Spain
Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Clin & Epidemiol Neurosci NeuroEpia, Reus, Catalonia, Spain
Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain
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