The heritability of insomnia: Systematic review and meta-analysis of twin studies.
Por:
Madrid-Valero JJ, Rubio-Aparicio M, Gregory AM, Sánchez-Meca J and Ordoñana JR
Publicada:
1 ago 2021
Ahead of Print:
21 ene 2021
Resumen:
Twin studies have consistently found that genetic factors explain a substantial proportion of the variance for insomnia. However, studies vary widely in their heritability estimates. Therefore, this meta-analysis aimed to: 1) Estimate the mean heritability of insomnia; 2) Assess heterogeneity among twin studies of insomnia; and 3) Search and analyse characteristics of the studies (moderator variables) that may explain heterogeneity among estimates. For this purpose, separate meta-analyses were carried out for MZ and DZ correlations and for heritability estimates by assuming random-effects models. Thirteen independent samples were included in this meta-analysis. The heterogeneity index for heritability estimates was significant in both best fitting models (I(2) = 98.77, P < .0001) and full models (I(2) = 97.80, P < .0001). MZ correlations were higher (0.37; 95%CI: 0.31,.43) than DZ correlations (0.15; 95%CI: 0.12,.18). A mean heritability of 0.39 (95%CI: 0.32,.44) was found for insomnia. These results highlight the role of genetic factors in explaining differences among the population on insomnia and Emphasize heterogeneity among studies. Further research is needed to identify variables that could explain this heterogeneity.
Filiaciones:
Madrid-Valero JJ:
Department of Health Psychology, Faculty of Health Science, University of Alicante, Spain
:
Department of Health Psychology, Faculty of Health Science, University of Alicante, Spain
Gregory AM:
Department of Psychology, Goldsmiths, University of London, London, United Kingdom
Sánchez-Meca J:
Department of Basic Psychology and Methodology, University of Murcia, Spain
Ordoñana JR:
Department of Human Anatomy and Psychobiology, University of Murcia, Spain
Murcia Institute of Biomedical Research, IMIB-Arrixaca, Spain
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