Preoperative sampling in endometrial cancer: evaluation of the histopathological agreement with definitive surgical specimen.
Por:
Quintana-Bertó R, Padilla-Iserte P, Gil-Moreno A, Oliver-Pérez R, Coronado PJ, Martín-Salamanca MB, Pantoja-Garrido M, Lorenzo C, Beric D, Gilabert-Estellés J, Sánchez L, Roldán-Rivas F, Díaz-Feijoo B, Rodríguez-Hernández JR, Marcos-Sanmartin J, Muruzábal JC, Cañada A and Domingo S
Publicada:
1 dic 2022
Ahead of Print:
19 ago 2022
Resumen:
PURPOSE: The main goal of this study is to assess the diagnostic agreement between preoperative biopsy and definitive histology of the surgical specimen to determine which sampling method is most suitable for diagnosis of early-stage endometrial cancer. METHODS: We performed a retrospective multicentric study to assess the correlation between three endometrial sampling methods (hysteroscopy, pipelle and D&C) in patients who had undergone preoperative endometrial biopsy and received primary surgical treatment for endometrial cancer. The primary objective was the agreement rate between hysteroscopy (HSC), endometrial biopsy (pipelle) and dilatation and curettage (D&C). RESULTS: A total of 1833 women who underwent preoperative sampling at 15 centers were included: 1042 biopsies were performed by HSC, 703 by pipelle and 88 by D&C. All three methods presented a moderate diagnostic concordance (? = 0.40-0.61) with the definitive specimen's histology: HSC (? = 0.47), pipelle sampling (? = 0.48) and D&C (? = 0.48). Likewise, a subgroup analysis was performed by histological subtype comparing HSC and endometrial biopsy, showing that neither is superior as a diagnostic method. CONCLUSIONS: According to this study, the use of pipelle sampling could become an adequate diagnostic method in endometrial cancer due to its similar agreement to HSC, ease of use and affordability.
Filiaciones:
Quintana-Bertó R:
Department of Gynecologic Oncology, La Fe University and Polytechnic Hospital, Av. Abril Martorell, 106, 46026, Valencia, Spain.
Padilla-Iserte P:
Department of Gynecologic Oncology, La Fe University and Polytechnic Hospital, Av. Abril Martorell, 106, 46026, Valencia, Spain
Gil-Moreno A:
Gynecologic Oncology Unit, Gynecology Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
Oliver-Pérez R:
Gynecologic Oncology-Unit, Department of Obstetrics and Gynecology, University Hospital 12 de Octubre, 12 de Octubre Research Institute, Complutense University of Madrid, Madrid, Spain
Coronado PJ:
Women's Health Institute of the Hospital Clínico San Carlos, IdISSC University Complutense, Madrid, Spain
Martín-Salamanca MB:
Gynecology Department, Hospital Universitario de Getafe, Madrid, Spain
Pantoja-Garrido M:
Department of Gynecology and Obstetrics, University Hospital Virgen Macarena, Seville, Spain
Lorenzo C:
Department of Obstetrics and Gynecology. Hospital, Nuestra Señora de la Calendaria, Tenerife, Spain
Beric D:
Department of Obstetrics and Gynecology, Hospital Universitario de Torrevieja, Alicante, Spain
Gilabert-Estellés J:
Department of Obstetrics and Gynecology, University General Hospital of Valencia, Valencia, Spain
Sánchez L:
Gynaecology and Obstetrics Department, University General Hospital of Ciudad Real, Castilla-La Mancha, Spain
Roldán-Rivas F:
Department of Obstetrics and Gynaecology, Clinico Lozano Blesa Hospital, Zaragoza, Spain
Díaz-Feijoo B:
Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic de Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
Rodríguez-Hernández JR:
Gynaecology and Obstetrics Department, University Hospital Virgen de La Arrixaca, El Palmar, Murcia, Spain
:
Department of Obstetrics and Gynecology, Hospital General Universitari D'Alacant, Alicante, Spain
Muruzábal JC:
Department of Gynecologic Oncology, Complejo Hospitalario de Navarra, Navarra, Spain
Cañada A:
Department of Biostatistics, Health Research Institute La Fe, Valencia, Spain
Domingo S:
Department of Gynecologic Oncology, La Fe University and Polytechnic Hospital, Av. Abril Martorell, 106, 46026, Valencia, Spain
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